The Science Behind LactoReborn™
Where Microbiome Science
Meets Visible Skin Renewal
The human body hosts over 100 trillion microbial cells — three times more than human cells. Among these, Lactobacillus paracasei plays a foundational role in how skin looks and feels, forming 90% of the birth canal microbiome and supporting the skin's protective surface from the very first moments of life.
When the skin microbiome falls out of balance — a state known as microbial dysbiosis — the consequences are visible at the skin's surface. Changes in microbiome balance are associated with the appearance of conditions including atopic dermatitis, visible signs of aging, and a compromised-looking skin surface.
"Lactobacillus paracasei makes up 90% of the birth canal's microbiome at the end of pregnancy — its extracellular vesicles help the newborn develop a healthy skin surface."
LactoReborn™ is formulated with probiotic-inspired extracellular vesicles (EVs) derived from L. paracasei, helping to maintain the skin's moisture barrier and support a more balanced-looking skin surface — without the concerns associated with live bacteria or synthetic compounds.
50–200nm Nanovesicles
Probiotic-inspired nanovesicles naturally sized to support visible skin surface renewal and help maintain the skin's moisture barrier.
Superior Safety Profile
No risk of uncontrollable proliferation. No genetic material. Derived from commensal bacteria with minimal safety concerns — ideal for sensitive skin.
cGMP Production
Produced in a certified cGMP-level in-house facility. The LactoReborn MDHC-011 strain ensures batch-to-batch consistency and cosmetic-grade quality.
Competitive Advantage
LactoReborn™ vs. Human Cell Exosomes
Microbial EVs establish a new benchmark in professional skincare
| Category | LactoReborn™ | Human Exosomes |
|---|---|---|
| Skin Penetration | Probiotic-inspired nanovesicles formulated to support visible results at the skin surface | Distributes only in the superficial epidermal layer |
| Antioxidant Activity | Comparable to Vitamin C; significantly superior to bone marrow, dermal fibroblast, and adipose stem cell exosomes | Lower antioxidant capacity across all tested exosome types |
| Production | Higher yield, cost-effective cGMP production, excellent storage stability | Low yield, high production cost, storage and stability challenges |
| Safety | No genetic material, no proliferation risk, commensal-derived | Risk of unintended genetic changes, proliferation concerns |
Study-Supported Results
Visible Results,
Measurably Superior
Validated across multiple peer-reviewed studies and assessments, demonstrating visible improvements that surpass conventional professional skincare including retinoic acid and human stem cell exosomes.
Skin Looks Firmer & Smoother
Human dermal fibroblast study — skin appearance superior to TGF-β at 5ng/ml
Superior to Retinoic Acid
Visible skin appearance outcomes surpass all-trans-retinoic acid in study conditions
Moisture Barrier Improvement
Transdermal water loss improvement — helps maintain the skin's moisture barrier
Clinical Photography
Real Patient Outcomes
Clinical photography showing visible improvements in skin appearance across a range of skin conditions following LactoReborn™ professional skincare protocols.
10 Sessions
Skin Texture & Radiance
Visible improvement in overall skin tone and surface texture following a complete LactoReborn™ protocol.
LactoReborn™ + PlazMagik
Atopic Dermatitis
Visible improvement in the appearance of skin associated with atopic dermatitis.
LactoReborn™ + PlazMagik
Atopic Dermatitis II
Continued visible improvement in skin comfort and appearance after a combined professional skincare protocol.
LactoReborn™ + PlazMagik
Riehl's Melanosis
Visible improvement in the appearance of pigmentation and skin clarity with a combined professional skincare approach.
LactoReborn™ + AGNES Ultra 3D
Pigmentation & Skin Texture
Improved appearance of pigmentation uniformity and skin texture combining probiotic-inspired technology with RF.
Real Patient Results
Clinical photography showing visible improvements in skin appearance following LactoReborn™ professional skincare protocols. Click any image to enlarge.
Professional Skincare Benefits
How Skin Looks & Feels
After LactoReborn™
LactoReborn™ is formulated to support visible skin renewal and help skin look and feel its best — as a standalone professional skincare step or as part of a post-procedure care protocol.
Helps Skin Look Firmer
Supports the appearance of firmer, smoother skin — visible improvement in the look of fine lines and surface texture.
Maintains Moisture Barrier
Helps maintain the skin's moisture barrier, supporting a more resilient-looking skin surface.
Soothes Skin Appearance
Calms the look of stressed-appearing skin — ideal as a post-procedure care step after professional treatments.
Revitalizes Skin Tone
Helps skin look more radiant and refreshed, supporting a more even, luminous appearance over time.
This product is intended for cosmetic use only and is not intended to diagnose, treat, cure, or prevent any disease.
Complete Your Protocol
Explore the Full Agnes Medical Collection
Each Agnes Medical technology is designed to complement the others — combine them to build comprehensive, differentiated treatment protocols.
Four Handpieces. Complete Regeneration.
The only RF platform with four specialized handpieces — Trace, Form, 3D, and Vibe — that triggers neocollagenesis and tissue remodeling from a single device.
Targeted Precision. Proven Results.
The original targeted RF microneedling platform — clinically validated for facial sculpting, acne treatment, and subdermal tissue remodeling with unmatched precision.
Dual Gas Plasma Technology.
FDA 510(k) cleared dual-gas cold atmospheric plasma (He + Ar). A non-contact finishing step that generates reactive molecules to support skin regeneration.
Experience the Future of
Advanced Topical Skincare
Discover how microbiome-inspired nanovesicle technology can support a more youthful skin appearance in your professional skincare protocols.
This product is intended for cosmetic use only and is not intended to diagnose, treat, cure, or prevent any disease.